Structure of PDB 5kbr Chain A

Receptor sequence
>5kbrA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAEVAIKQELIINEILVMR
ENKNPNIVNYLDSYWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA
LEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFCAKRSEMVGTPYWMAP
EVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPE
LQNPEKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPL
IAAAKEATK
3D structure
PDB5kbr Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.
ChainA
Resolution2.36 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N389 K391 D393 N394 D407 T427
Catalytic site (residue number reindexed from 1) N113 K115 D117 N118 D131 T144
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IPW A I276 V284 A297 K299 V328 V342 M344 E345 Y346 L347 L396 T406 I22 V30 A36 K38 V58 V66 M68 E69 Y70 L71 L120 T130 MOAD: ic50=260nM
PDBbind-CN: -logKd/Ki=6.59,IC50=260nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5kbr, PDBe:5kbr, PDBj:5kbr
PDBsum5kbr
PubMed27994749
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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