Structure of PDB 5kal Chain A

Receptor sequence
>5kalA (length=325) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
PPSPAVVGRSLVNSFKQFVSHVDATYRLVLDCVAAVDPLMRLYTFGSTVV
YGVHEKGSDVDFVVLNKTDVEDGKGGDAATQVAKGLQADILAKLARVIRQ
KHLSWNVEEVRRTRVPVVRVKGGGAVDFDITAYRRNGVRNSALLRAYFEQ
NPPCRWLSMSIKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQRNHLQF
VPPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLHFFLHEFDSDKQ
VISLNRPGITTKEELDWTKSAEDFARMNGEKVHYQWCIEDPYELNLNVGR
NVTPLKRDFLRRHLEKARDTALLTI
3D structure
PDB5kal RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A D68 V117 D61 V110
BS02 UTP A F52 S54 G144 N147 S148 K169 K173 S188 Y189 F45 S47 G137 N140 S141 K162 K166 S181 Y182
BS03 MG A D66 D68 D59 D61
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
Biological Process
GO:0071076 RNA 3' uridylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0020023 kinetoplast

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Cellular Component
External links
PDB RCSB:5kal, PDBe:5kal, PDBj:5kal
PDBsum5kal
PubMed27744351
UniProtQ381M1|TUT4_TRYB2 Terminal uridylyltransferase 4 (Gene Name=TUT4)

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