Structure of PDB 5k9s Chain A

Receptor sequence
>5k9sA (length=425) Species: 10090 (Mus musculus) [Search protein sequence]
VNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPK
FVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLAS
PHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLAC
GYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCW
AISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTG
TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQV
VNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIE
PLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKI
EALQRHENESVYKASLNLIEKYFSV
3D structure
PDB5k9s Importin-alpha in complex with HNF1-beta peptide
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R101 S105 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 W273 R28 S32 W69 N73 S76 G77 T82 Q108 W111 N115 G118 D119 W158 R165 W200
BS02 peptide A R315 V321 T328 E354 W357 N361 N403 R242 V248 T255 E281 W284 N288 N330
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5k9s, PDBe:5k9s, PDBj:5k9s
PDBsum5k9s
PubMed
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

[Back to BioLiP]