Structure of PDB 5k8k Chain A

Receptor sequence
>5k8kA (length=237) Species: 71421 (Haemophilus influenzae Rd KW20) [Search protein sequence]
MKHSYFISDLHLSETQPELTALFVDFMQNLAPQAERLYILGDLFDFWIGD
DEQSALIQQVKDLIKFVSDQGVQCYFQHGNRDFLIGERFSKETGAQLLPD
YQLITLYDKKILLCHGDTLCIDDEAYQQFRRRVHQKWLQRLFLCLPLKVR
VIIAEKIRAKSNQDKQAKSQEIMDVNQAFTAEKVQEFGVNLLIHGHTHRE
AIHQQEEFTRIVLGDWRKNYASILKMDESGEFGFIKD
3D structure
PDB5k8k Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D42 N80 H115 H196 D42 N80 H115 H196
BS02 MN A D9 H11 D42 D9 H11 D42
BS03 LP5 A N80 R81 D123 Y126 F129 L138 Q139 F142 R158 K160 S161 D164 K165 K168 M173 H196 H198 N80 R81 D123 Y126 F129 L138 Q139 F142 R158 K160 S161 D164 K165 K168 M173 H196 H198
Gene Ontology
Molecular Function
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009245 lipid A biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0019897 extrinsic component of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5k8k, PDBe:5k8k, PDBj:5k8k
PDBsum5k8k
PubMed27780190
UniProtP44046|LPXH_HAEIN UDP-2,3-diacylglucosamine hydrolase (Gene Name=lpxH)

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