Structure of PDB 5k8d Chain A

Receptor sequence
>5k8dA (length=611) Species: 9606 (Homo sapiens) [Search protein sequence]
ATRRYYLGAVELSWDYMVVYKKTLFVEFTDHLFRPPWMGLLGPTIQAEVY
DTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPG
GSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCRE
GSLAKEKTQTLHKFILLFAVFDEGKSWWPKMHTVNGYVNRSLPGLIGCHR
KSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLL
MDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQAKKHPKTWVHYIAAEE
EDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTRE
AIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRR
LPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNME
RDLASGLIGPLLICYRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLED
PEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSG
YTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTAL
LKVSSCDKNTG
3D structure
PDB5k8d The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.
ChainA
Resolution4.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D116 E122 K123 D126 D85 E91 K92 D95
BS02 CA A S535 N538 M539 E540 D542 S445 N448 M449 E450 D452
BS03 CA A K107 A108 E122 D125 D126 K76 A77 E91 D94 D95
BS04 CU A H267 C310 H315 H217 C260 H265
Gene Ontology
Molecular Function
GO:0005507 copper ion binding

View graph for
Molecular Function
External links
PDB RCSB:5k8d, PDBe:5k8d, PDBj:5k8d
PDBsum5k8d
PubMed28397397
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8)

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