Structure of PDB 5k5s Chain A

Receptor sequence
>5k5sA (length=531) Species: 9606 (Homo sapiens) [Search protein sequence]
YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFL
RTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD
ICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIV
RRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFL
KKVHPRKSVHNGFAKEFWEETFNCHPLCTGDENINSVETPYIDYTHLRIS
YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHL
QFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKK
GERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVE
CPDGEYSDETDASACNKCPDDFWSNENHTSC
3D structure
PDB5k5s Structural mechanism of ligand activation in human calcium-sensing receptor.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TRP A R66 W70 S147 A168 S169 S170 Y218 E297 A298 R47 W51 S113 A134 S135 S136 Y184 E263 A264 PDBbind-CN: -logKd/Ki=2.69,IC50=2.04mM
BS02 CA A I81 N82 S84 L87 L88 I62 N63 S65 L68 L69
BS03 CA A F38 P39 T100 A144 T145 F19 P20 T81 A110 T111
BS04 CA A E231 D234 E197 D200
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5k5s, PDBe:5k5s, PDBj:5k5s
PDBsum5k5s
PubMed27434672
UniProtP41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)

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