Structure of PDB 5k5m Chain A

Receptor sequence
>5k5mA (length=563) Species: 11060 (dengue virus type 2) [Search protein sequence]
NLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKSSMVNGVVRL
LTKPWDVVPMVTQMAMEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKT
PRMCTREEFTRKVRSNWKSAREAVEDSRFWELVDKERNLHLEGKCETCVY
NMMRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYI
LRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAI
FKLTYQNKVVRVQRPTVMDIISRRDQRGSTYGLNTFTNMEAQLIRQMEGE
GVFKSIQHLTVTEEIAVQNWLARVGRERLSRMAISGDDCVVKPLDDRFAS
ALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVV
PCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRDLRLAA
NAICSAVPSHWVPTSRTTWSIHAKHEWMTTEDMLTVWNRVWIQENPWMED
KTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGN
EEYTDYMPSMKRF
3D structure
PDB5k5m Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
ChainA
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H712 H714 C728 C847 H386 H388 C402 C521
BS02 ZN A E438 H442 C447 C450 E136 H140 C145 C148
BS03 68T A L512 C709 R729 R737 M761 M765 T794 S796 H798 A799 K800 E802 W803 L194 C383 R403 R411 M435 M439 T468 S470 H472 A473 K474 E476 W477
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5k5m, PDBe:5k5m, PDBj:5k5m
PDBsum5k5m
PubMed27500641
UniProtA0A097PIE2

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