Structure of PDB 5k5i Chain A

Receptor sequence

>5k5iA (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]

SPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHI
LQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVF
HERYALIQHQKSH

3D structure

PDB

5k5i Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

2.19 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Y392 R457	Y16 R81
BS02	dna	A	Y386 K393 R396 H397 T400 F416 Q418 T421 H425 R448 D451 H455 Q459 R479	Y10 K17 R20 H21 T24 F40 Q42 T45 H49 R72 D75 H79 Q83 R103
BS03	ZN	A	C381 C384 H397 H401	C5 C8 H21 H25
BS04	ZN	A	C409 H425 H430	C33 H49 H54
BS05	ZN	A	C439 C442 H455 H460	C63 C66 H79 H84
BS06	ZN	A	C469 H485 H489	C93 H109 H113
BS07	ZN	A	H441 E478	H65 E102

External links

PDB	RCSB:5k5i, PDBe:5k5i, PDBj:5k5i
PDBsum	5k5i
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)