Structure of PDB 5k5h Chain A

Receptor sequence

>5k5hA (length=111) Species: 9606 (Homo sapiens) [Search protein sequence]

PFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMR
THSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARK
SDLGVHLRKQH

3D structure

PDB

5k5h Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

3.108 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Y358 K365 R368 H369 Y386 R389 K393 R396 Q418 T421 H425 K429 R448	Y9 K16 R19 H20 Y37 R40 K44 R47 Q69 T72 H76 K80 R99	PDBbind-CN: Kd=30nM
BS02	dna	A	Y392 K395 Y407 S419 K423 K449 S450 R457	Y43 K46 Y58 S70 K74 K100 S101 R108	PDBbind-CN: Kd=30nM
BS03	ZN	A	C356 H369 H373	C7 H20 H24
BS04	ZN	A	C381 C384 H397 H401	C32 C35 H48 H52
BS05	ZN	A	C409 C412 H425 H430	C60 C63 H76 H81
BS06	ZN	A	C442 H455 H460	C93 H106 H111

External links

PDB	RCSB:5k5h, PDBe:5k5h, PDBj:5k5h
PDBsum	5k5h
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)