Structure of PDB 5k4z Chain A

Receptor sequence
>5k4zA (length=332) Species: 1797 (Mycolicibacterium thermoresistibile) [Search protein sequence]
VPTGGDDPTKIAMLGLTFDDVLLLPAASDVLPANADTSSQLTKKIRLKVP
LVSSAMDTVTEARMAIAMARAGGMGVLHRNLPVAEQAAQVETVKRSGGLL
VGAAVGVGDDAWERAMALRDAGVDVLVVDTAHAHNRKVLDMVHRLKTTVG
DEIEVVGGNVATRAAAAALVEAGADAVKVGVGPGSICTTRVVAGVGAPQI
TAILEAVAACAPHGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTA
ESPGELILVNGKQFKSYRGMGSLGAMQLVPEGIEGRVPFRGPLSTVIHQL
VGGLRAAMGYTGSATIEELQQAQFVQITAAGL
3D structure
PDB5k4z Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.
ChainA
Resolution1.64 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A S68 M70 G198 S199 I200 C201 D234 G257 S258 Y281 G283 M284 G285 E318 G319 S54 M56 G184 S185 I186 C187 D220 G243 S244 Y267 G269 M270 G271 E281 G282
BS02 6Q8 A T144 A145 N149 V195 M284 G285 E318 T130 A131 N135 V181 M270 G271 E281 MOAD: Kd=0.7uM
PDBbind-CN: -logKd/Ki=6.15,Kd=0.7uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5k4z, PDBe:5k4z, PDBj:5k4z
PDBsum5k4z
PubMed27704782
UniProtG7CNL4

[Back to BioLiP]