Structure of PDB 5k4w Chain A

Receptor sequence

>5k4wA (length=320) Species: 5691 (Trypanosoma brucei) [Search protein sequence]

MPRVLVTGALGQIGTDLSLALRDKFGADSVLVSDVVEPGAKHPLAGLKGV
EKLDCLDSNGFEKLVKEFKPTWMYHLPAIMSVRGEAEPDLAMDINVNTTR
YALELARKYNIRIFIPSTIAAFGDKCGKTMTKDDTIMNPSTVYGVTKVYT
ELLGTWYRQKYGVDFRSVRLPGIISAATLPGGGATDYAIHMYHSALLQKK
CVCPVLPYESLPMMYMPDTLNSLVKIMEAPLEKLTRTVYNITGFSFSPSE
LRFSIERCTDRTIEVEYVEGPAQKIANSWPDSLDDSNARNDWGHQVKYDI
DMMSEDMLRQIPILHGLPSL

3D structure

PDB

5k4w Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.

Chain

Resolution

1.72 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.103: L-threonine 3-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAI	A	G1009 G1012 Q1013 I1014 D1035 V1036 D1055 C1056 L1077 P1078 A1079 M1081 I1095 P1117 S1118 T1119 Y1144 K1148 L1171 I1174	G8 G11 Q12 I13 D34 V35 D54 C55 L76 P77 A78 M80 I94 P116 S117 T118 Y143 K147 L170 I173
BS02	THR	A	M1081 S1082 T1119 Y1144 G1184 A1185 T1186 W1280	M80 S81 T118 Y143 G183 A184 T185 W279

External links

PDB	RCSB:5k4w, PDBe:5k4w, PDBj:5k4w
PDBsum	5k4w
PubMed	30198897
UniProt	Q7YW97

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