Structure of PDB 5k13 Chain A

Receptor sequence
>5k13A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSE
LSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPE
QDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLS
AICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMK
ITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
3D structure
PDB5k13 Identification of potent and selective retinoic acid receptor gamma (RAR gamma ) antagonists for the treatment of osteoarthritis pain using structure based drug design.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6Q7 A W225 F228 S232 C235 L266 L269 I270 I273 F286 S287 G301 F302 V395 P407 W45 F48 S52 C55 L86 L89 I90 I93 F106 S107 G121 F122 V215 P227 MOAD: Ki=1.8nM
PDBbind-CN: -logKd/Ki=8.74,Ki=1.8nM
BindingDB: Ki=1.8nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5k13, PDBe:5k13, PDBj:5k13
PDBsum5k13
PubMed27261179
UniProtP10276|RARA_HUMAN Retinoic acid receptor alpha (Gene Name=RARA)

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