Structure of PDB 5jzn Chain A

Receptor sequence
>5jznA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
GFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRG
KEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAIT
STNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKS
LKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITY
ILLCGFPPFRGSDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLV
DVDQRFSAVQVLEHPWVN
3D structure
PDB5jzn Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D511 K513 E515 N516 D533 T550
Catalytic site (residue number reindexed from 1) D133 K135 E137 N138 D155 T172
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GUI A V404 K419 V468 G471 L518 V26 K41 V90 G93 L140 PDBbind-CN: -logKd/Ki=5.96,IC50=1084nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5jzn, PDBe:5jzn, PDBj:5jzn
PDBsum5jzn
PubMed27545623
UniProtO15075|DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (Gene Name=DCLK1)

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