Structure of PDB 5jxs Chain A

Receptor sequence

>5jxsA (length=476) Species: 12110 (Foot-and-mouth disease virus)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVAANPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAAALEH

3D structure

• PDB: 5jxs Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	L108 D109 T115 A116 R128 F162 L163 D165 V181 V183 R193 A216 N218 G299 C300 S301 T303 Y336	L108 D109 T115 A116 R128 F162 L163 D165 V181 V183 R193 A216 N218 G299 C300 S301 T303 Y336
BS02	rna	A	D114 Y336 D338 D339 L386 K387 I411 R416 E422 K423 S426 L430	D114 Y336 D338 D339 L386 K387 I411 R416 E422 K423 S426 L430
BS03	MG	A	D240 D339	D240 D339

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:5jxs, PDBe:5jxs, PDBj:5jxs
• PDBsum: 5jxs
• PubMed: 27194768
• UniProt: P03311|POLG_FMDVS Genome polyprotein