Structure of PDB 5jwg Chain A

Receptor sequence

>5jwgA (length=703) Species: 28124 (Porphyromonas endodontalis)

MDGGMWLMQQINGQVARMKSLGMQLEAADIYNPNGSSLKDAVVMFDGGCT
GVLVSNQGLLLTNHHCGYDQIQKHSSVQHNYLKDGFWSYSLAEELVNPGL
EVEIVDEITDVTAAVKKELERIKKPSGLEFLSPRYLSSLAPEIVGKKAAS
RPGYRYEIKAFYGGNRYYMFTKKVFRDVRLVAAPPSSIGKFGSDTDNWAW
PRHTGDFSIFRLYADKNGNPAEYSKDNVPYRPKRWVKVNAQGVKEGDFAL
IMGYPGTTYKFFTADEVTEWSEIDNNIRIEMRGILQDVMLREMLADPKIN
IMYAAKYASSQNGYKRAQGANWAIRRRSLREIKLAQQQEVLAWAKQKGIA
TTEEAVRAISKAIEGRQDLRMRQRYLLEGILMGIEMSNAPAADSDIADHW
DDPARREAGLQSIRKQFEAFFNKDYSPEVEKDQLAIALLTRYAERIPAEK
QPISIREGIAEYGSAKAYVEMIFDKSIYASRERFEEFMKNPDRDRLLRDP
MSRFAASVAYEHQKLAKEVAAFDAPLAAAQRSYVASVLDMKGQPNLAPDA
NLTLRFTYGEIKGYQPRDVVTYGAKSTLEGVMEKEDPNNWEYVVDPKLKA
LYEAKNYGRYANSDGSMPVNFCATTHTTGGNAGSPVMNARGELIGLNFDR
NWEGVGGDIEYLPNYQRSIILDIRYLLFIIDKFAGCQRLIDEIQPQFHHH
HHH

3D structure

• PDB: 5jwg Bacterial protease uses distinct thermodynamic signatures for substrate recognition.
• Chain: A
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 3.4.14.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ARG	A	H85 N217 W218 N332 D669	H65 N197 W198 N312 D649
BS02	ASP	A	H85 W218 T648 G649 G650 A652 R670	H65 W198 T628 G629 G630 A632 R650

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0008239 dipeptidyl-peptidase activity
• GO:0070009 serine-type aminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0043171 peptide catabolic process

Cellular Component

• GO:0005576 extracellular region
• GO:0009986 cell surface

External links

• PDB: RCSB:5jwg, PDBe:5jwg, PDBj:5jwg
• PDBsum: 5jwg
• PubMed: 28588213
• UniProt: F8WQK8|DPP11_POREA Asp/Glu-specific dipeptidyl-peptidase (Gene Name=dpp11)