Structure of PDB 5jvt Chain A

Receptor sequence
>5jvtA (length=96) Species: 9606 (Homo sapiens) [Search protein sequence]
GQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPT
3D structure
PDB5jvt Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y332 R337 R340 Y343 K350 R355 Y356 Y54 R59 R62 Y65 K72 R77 Y78
BS02 dna A Q282 L283 W321 K327 M330 K334 Y342 K345 Q4 L5 W43 K49 M52 K56 Y64 K67
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5jvt, PDBe:5jvt, PDBj:5jvt
PDBsum5jvt
PubMed27587584
UniProtQ01543|FLI1_HUMAN Friend leukemia integration 1 transcription factor (Gene Name=FLI1)

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