Structure of PDB 5jtc Chain A

Receptor sequence

>5jtcA (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]

KPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRARY
GKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDR
QQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEE
VLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYF
HLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPK
ETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFT
LWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPH
TGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFDDSFEHEVWQ
DASSFRLIFIVDVWHPELTPQQRRSLPAI

3D structure

PDB

5jtc Aspartate/asparagine-beta-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Chain

Resolution

2.24 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.11.16: peptide-aspartate beta-dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	A389 E390 R393 S394 N395 F432 L433 H493 F496 R526 F529 H530 Y565 D616 E617 T680 G681 P682 R686 R688 I758	A60 E61 R64 S65 N66 F103 L104 H164 F167 R197 F200 H201 Y236 D287 E288 T351 G352 P353 R357 R359 I429
BS02	MN	A	H679 H725	H350 H396
BS03	PD2	A	W625 S668 M670 H679 R688 H690 H725 V727 R735	W296 S339 M341 H350 R359 H361 H396 V398 R406

Gene Ontology

	Molecular Function
GO:0062101	peptidyl-aspartic acid 3-dioxygenase activity

	Biological Process
GO:0018193	peptidyl-amino acid modification
GO:0042264	peptidyl-aspartic acid hydroxylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5jtc, PDBe:5jtc, PDBj:5jtc
PDBsum	5jtc
PubMed	32457455
UniProt	Q12797\|ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (Gene Name=ASPH)

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