Structure of PDB 5jr6 Chain A

Receptor sequence
>5jr6A (length=628) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
DNNPAARLEELRTIMKKNKIDVYILINSDEHNSEIINEKDKKIVKITNYS
GADGILIVTKDKPILYVNALYELQAMNELDQNLFTLRISRIDNRDEIFET
ISSLFNTIAFDGKNTSVVFYEKLRKALLNAYPKKKIVEKIIYNNNFDDVL
NFLVLEKSLVEIYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNV
DNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDREQDFSKIVFFTT
VKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIPKDFKKYDISLSP
YINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQ
FFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPN
AAVIHYECTDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEK
RIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGV
GLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVI
SKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTL
LPLVKQSPQEYGESVEKYLIEITEPIAI
3D structure
PDB5jr6 Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.9: Xaa-Pro aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I163 F537 D570 D581 H640 G641 G643 H644 V652 H653 E676 I35 F391 D424 D435 H494 G495 G497 H498 V506 H507 E530
BS02 MN A D581 H644 E676 E690 D435 H498 E530 E544
BS03 MN A D570 D581 E690 D424 D435 E544
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:5jr6, PDBe:5jr6, PDBj:5jr6
PDBsum5jr6
PubMed27462122
UniProtA0A144A2H0|AMPP_PLAF7 Aminopeptidase P (Gene Name=APP)

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