Structure of PDB 5jq9 Chain A

Receptor sequence
>5jq9A (length=257) Species: 687916 (Yersinia pestis KIM D27) [Search protein sequence]
MHLTARGLTLDLSRPQVMGILNVTPNLDQALQHAQRMLSAGATLIDIGGE
STRAAEVSEQEELDRVVPVVEALAQRFDVWLSVDTSKAAVITESAHAGAH
LINDIRSLQEPGALEAAAKTGLPVCLMHMQQHSPYYDDLMTDINRFFQHH
IERCVAAGIAKNKLLLDPGFGFGKNLAHNYQLLAHLSELHHFELPLLVGM
SRKSMVGQLLNVPPQQRVIGSVACAVIAAMQGAQIIRVHDVKETVEAMCI
VEATRSA
3D structure
PDB5jq9 Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.
ChainA
Resolution2.101 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K221 R255
Catalytic site (residue number reindexed from 1) K203 R237
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6MB A D96 N115 I117 D185 G189 F190 G217 K221 S222 R255 D84 N103 I105 D167 G171 F172 G199 K203 S204 R237 PDBbind-CN: -logKd/Ki=4.65,IC50=22.5uM
Gene Ontology
Molecular Function
GO:0004156 dihydropteroate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5jq9, PDBe:5jq9, PDBj:5jq9
PDBsum5jq9
PubMed27423480
UniProtA0A2S9PLG4

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