Structure of PDB 5jk5 Chain A

Receptor sequence
>5jk5A (length=400) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
QSYHSSIFFSISKGSDKIGGLLEYLEIIKKHNINITRIESRPSKTEKKDY
DFFLDLEYPTENNKEVEKVIKDLEEKGVKATTLQESSNQTYAPWFPRKIS
DLDLFANKVLEMGSDLTSDHPGASDPVYRERRREIAKIASTYKHGDEIPR
IDYTEEEIKTWGVVYNRLKELFPTNACHQHAYIFPLLEQNCGYSPDNIPQ
LQDISNFLQECTGWRIRPVQGLLSARDFLNGLAFRVFHATQYIRHPSVPL
YTPEPDCCHELLGHVPLLADPDFADFSQEIGLASIGASDEDIQLLSTCYW
FTVEFGLCKEGDTIRAYGAGILSSTGEMEHFLTDKAKKLPFNPFDACNTE
YPITTFQPLYYVAESFQKAKEQMRQFADSFKKPFSIRYNPYTQSIEILDN
3D structure
PDB5jk5 Phenylalanine hydroxylase from dictyostelium - BH2 complex
ChainA
Resolution2.071 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H273 H278 E318 S337
Catalytic site (residue number reindexed from 1) H259 H264 E304 S323
Enzyme Commision number 1.14.16.1: phenylalanine 4-monooxygenase.
1.14.16.4: tryptophan 5-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H273 H278 E318 H259 H264 E304
BS02 PIN A T226 P285 D289 R388 T212 P271 D275 R374
BS03 HBI A G235 L236 L237 F242 L243 S310 Y313 G221 L222 L223 F228 L229 S296 Y299
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004505 phenylalanine 4-monooxygenase activity
GO:0004510 tryptophan 5-monooxygenase activity
GO:0004664 prephenate dehydratase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0034617 tetrahydrobiopterin binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006571 tyrosine biosynthetic process
GO:0009072 aromatic amino acid metabolic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine
GO:0019954 asexual reproduction
Cellular Component
GO:0005575 cellular_component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5jk5, PDBe:5jk5, PDBj:5jk5
PDBsum5jk5
PubMed
UniProtQ54XS1|PH4H_DICDI Phenylalanine-4-hydroxylase (Gene Name=pah)

[Back to BioLiP]