Structure of PDB 5jil Chain A

Receptor sequence
>5jilA (length=369) Species: 31632 (Rat coronavirus) [Search protein sequence]
FNEPLNIVSHLNDDWFLFGDARSDCTYVENNGHPKLDWLDLDPKLCNSGR
ISAKSGNSLFRSFHFTDFYNYSGEGDQVIFYEGVNFSPSHGFKCLANGDN
KIWMGNKARFYARLYEKMAQYRSLSIVTVSYAYGGNAKPTSICKDNKLTL
NNPTFISKESNYADYYYVSEANFTLQGCDEFIVPLCVFNGHSRGSSSDPA
NTYYMDSQMYYNTVTGVFYGFNSTLDVGTTVQNPGLDLTCSYLALSPGNY
KAVSLEFLLSLPSKAICLLKPKRFMPVQVVDSRWNSTRQSDNMTAVACQL
PYCFFRNTSADYSGDTHDVHHGDLYFRQLLSGLLYNVSCIAQQGAFLYNN
VSSIWPVYGYGHCPTAANI
3D structure
PDB5jil Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.53: sialate O-acetylesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E48 H52 D56 H336 E29 H33 D37 H317
BS02 6KL A A40 Y46 W57 S74 G75 N104 H336 H340 A21 Y27 W38 S55 G56 N85 H317 H321
BS03 6KL A F207 S211 R212 G213 S214 S215 T248 F276 F188 S192 R193 G194 S195 S196 T229 F257
Gene Ontology
Molecular Function
GO:0001681 sialate O-acetylesterase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
Cellular Component
GO:0019031 viral envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5jil, PDBe:5jil, PDBj:5jil
PDBsum5jil
PubMed27185912
UniProtQ3HS77

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