Structure of PDB 5jic Chain A

Receptor sequence
>5jicA (length=269) Species: 196620 (Staphylococcus aureus subsp. aureus MW2) [Search protein sequence]
KVGIDAGGTLIKIVQEQRTFKTELTKNIDQVVEWLNQQQIEKLCLTGGNA
GVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTGTSLH
YFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRNTIDL
KVRHIYKDTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVVGEVV
TTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVENG
AFSGAIGALYLEKHHHHHH
3D structure
PDB5jic Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 S225 S226 G7 G8 T9 L10 K12 G94 T95 G117 Q121 Y133 S221 S222
BS02 N7E A E70 G100 R113 G116 I117 E66 G96 R109 G112 I113 MOAD: ic50=0.13uM
PDBbind-CN: -logKd/Ki=6.89,IC50=0.13uM
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5jic, PDBe:5jic, PDBj:5jic
PDBsum5jic
PubMed27759386
UniProtQ2FWC7|COAW_STAA8 Type II pantothenate kinase (Gene Name=coaW)

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