Structure of PDB 5jhq Chain A

Receptor sequence

>5jhqA (length=462) Species: 9606 (Homo sapiens) [Search protein sequence]

GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKD
VVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN
WNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVL
TGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN
RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA
MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL
RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV
ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH
GAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM
GNEAVQQILSES

3D structure

PDB

5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R215 S217 F222 G225 F226 L250 N255 S258 F259 H261 D279 W281 Y283 E288	R35 S37 F42 G45 F46 L70 N75 S78 F79 H81 D99 W101 Y103 E108
BS02	peptide	A	R368 S370 L375 G378 Y379 N408 Y412 H414 D432 W434 F436 E441 R447	R188 S190 L195 G198 Y199 N228 Y232 H234 D252 W254 F256 E261 R267

External links

PDB	RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum	5jhq
PubMed	27594684
UniProt	O95271\|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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