Structure of PDB 5jgk Chain A

Receptor sequence
>5jgkA (length=281) Species: 1437362 (Aspergillus fumigatus Z5) [Search protein sequence]
IQNMFQTKSFVDRYKYTEKLTGLYAQTLVDYSGVANTSQKPLIVLDNACG
IGAVSSVLNHTLQDEAKKTWKLTCGDLSEGMLETTKRRLQDEGWVNAETK
IVNALDTGLPDGHYTHVFVAFGFQSFPDANAALKECFRILASGGILASST
WQNFNWIPIMKAAIETIPGNLPFPTQKEFIALHNAGWDSESYIQSELEKL
GFRDVKVIPVPKETSIPIDEFFEVCMMIIPYLLPKFWTEEQRESHEKDVP
MVLRQYLQDTYGANGQVPLEAVALITTGLKP
3D structure
PDB5jgk Structural, mechanistic and functional insight into gliotoxinbis-thiomethylation inAspergillus fumigatus.
ChainA
Resolution1.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.9: thiol S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F11 Y20 T27 A54 C55 G56 D82 L83 N109 A110 A126 F127 F132 F5 Y14 T21 A48 C49 G50 D76 L77 N103 A104 A120 F121 F126 MOAD: Kd=12.6uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5jgk, PDBe:5jgk, PDBj:5jgk
PDBsum5jgk
PubMed28179499
UniProtQ4X158|TMTA_ASPFU Gliotoxin thiomethyltransferase GtmA (Gene Name=tmtA)

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