Structure of PDB 5jcf Chain A

Receptor sequence

>5jcfA (length=660) Species: 9031 (Gallus gallus) [Search protein sequence]

GDLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKA
SEQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEV
VKRYDVIICTAQILENSLLNATEESVRLSDFSLIIIDQCHHTQKEGVYNN
IMRRYLKEKIKNRKQAKELIPQPQILGLTASPGVGGARSNSKAEEHILKI
CANLDACRIMTVKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQ
DIQKYCQLYPKSEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYND
ALQINDTIRMVDAYNHLNNFYKELKRRKTAESDDDSKQDETDEFLMRLFH
AKKKQLKELARKPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSAL
ALYHWIMDNPKFEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGS
INLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYAL
VASSGSGAVEREDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIV
EKQMKAKRDQRITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYHK
RENQTNVEIICKDCGQVWGNMMVYRGLDLPCLKIRNFVVAFEDTKEIFKK
WGELPIIFPD

3D structure

PDB

5jcf Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K442 E443 Q568 Q572 H733 T785 R817 M900	K144 E145 Q267 Q271 H427 T479 R511 M585
BS02	rna	A	N357 K358 V359 G385 T406 Q408 N412 K700 R702 G730 S735 T763 T764 V765 K977	N61 K62 V63 G89 T110 Q112 N116 K394 R396 G424 S429 T457 T458 V459 K649
BS03	ADP	A	R302 Q305 T324 G325 G327 K328 R330	R6 Q9 T28 G29 G31 K32 R34
BS04	ZN	A	C881 C884 C936 C939	C566 C569 C611 C614

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity

View graph for
Molecular Function

External links

PDB	RCSB:5jcf, PDBe:5jcf, PDBj:5jcf
PDBsum	5jcf
PubMed	27203181
UniProt	D9N195

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