Structure of PDB 5jbj Chain A

Receptor sequence

>5jbjA (length=627) Species: 9031 (Gallus gallus)

SELHGYQLEAVAPALRGRNSIVWLPTGAGKTRAAVHVCRRHLEGRRGGRV
AVLVNKVHLVQQHLEKEFHVLRDAFKVTAVSGDSSHKCFFGQLAKGSDVV
ICTAQILQNALLSGEEEARVELTDFSLLVIDECHHTQKEAVYNKIMLSYL
QKKLSGQRDLPQILGLTASPGTGGETSFEGAVEHILQICANLDTEVIASA
REQDPFGQRLKKIMAQIQEHMEMPELPQNFGTQVYEQRIVELENRAAERF
CRKTRVCALHLRRYNDALLINDTVRMMDAFQCLQQFYADKDPTERFLATT
FEENRATLQALAGDQRYNPRLSKLEEILQEHFQPPGSSRGIVFTKTRQSA
HSLLSWLQDTAGLCGQHIRAAVLTGSGHSNQAKGMTQNEQQDVITLFRYG
ELNLLFSTSVAEEGLDIPECNIVVRYGLMTNEIAMVQAQGRARAQNSMYS
VLAKANLMERAIRAVQAMPERKYRLKIVELQRNAVLSWQVKEARSSERRQ
LHDPDDVYFHCVNCNVAVCRGSDIRTVEAMHHVNINPNFRFYYTVSSGKI
HFERTFRDWEPGCRIVCSECRQEWGMEMIYRNVTLPILSIKNFVVVTPDE
KKKYKKWSTVTFPIEEFSYLEYCSSTQ

3D structure

• PDB: 5jbj Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
• Chain: A
• Resolution: 3.58 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K138 E139 Q256 V257 Q260 R261 H406 K411 M573 H574 F595 R607 M619 S632 W650	K138 E139 Q233 V234 Q237 R238 H378 K383 M530 H531 F552 R564 M576 S589 W607
BS02	rna	A	N55 K56 V57 G82 S85 T103 Q105 N109 Q260 R285 K373 T374 R375 T402 G403 Q409 Q415 T436 V438 E571 M573 H574 R597 F599 W602 K648	N55 K56 V57 G82 S85 T103 Q105 N109 Q237 R262 K345 T346 R347 T374 G375 Q381 Q387 T408 V410 E528 M530 H531 R554 F556 W559 K605
BS03	ZN	A	C554 C557 C610 C613	C511 C514 C567 C570

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0045087 innate immune response

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5jbj, PDBe:5jbj, PDBj:5jbj
• PDBsum: 5jbj
• PubMed: 27203181
• UniProt: G0YYQ5