Structure of PDB 5jbg Chain A

Receptor sequence

>5jbgA (length=661) Species: 9031 (Gallus gallus)

SELHGYQLEAVAPALRGRNSIVWLPTGAGKTRAAVHVCRRHLEGRRGGRV
AVLVNKVHLVQQHLEKEFHVLRDAFKVTAVSGDSSHKCFFGQLAKGSDVV
ICTAQILQNALLSGEEEARVELTDFSLLVIDECHHTQKEAVYNKIMLSYL
QKKLSGQRDLPQILGLTASPGTGGETSFEGAVEHILQICANLDTEVIASA
QEVPQPTKQYDLCQEREQDPFGQRLKKIMAQIQEHMEMPELPQNFGTQVY
EQRIVELENRAAERFCRKTRVCALHLRRYNDALLINDTVRMMDAFQCLQQ
FYADKKDPTERFLATTFEENRATLQALAGDQRYENPRLSKLEEILQEHFQ
PGSSRGIVFTKTRQSAHSLLSWLQDTAGLCGQHIRAAVLTGSGHSNQAKG
MTQNEQQDVITLFRYGELNLLFSTSVAEEGLDIPECNIVVRYGLMTNEIA
MVQAQGRARAQNSMYSVLAKANSREVYREQLNESLVGLMERAIRAVQAMP
ERKYRLKIVELQRNAVLSWQVKEARSSERRQLHDPDDVYFHCVNCNVAVC
RGSDIRTVEAMHHVNINPNFRFYYTVSSGKIHFERTFRDWEPGCRIVCSE
CRQEWGMEMIYRNVTLPILSIKNFVVVTPDEKKKYKKWSTVTFPIEEFSY
LEYCSSTQDES

3D structure

• PDB: 5jbg Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K56 V57 V80 S81 G82 S84 K87 C88 F89 F90 L93 T103 Q105 I106 N109 K138 E139 A140 Q256 E259 Q260 V263 E264 K373 T374 R375 T402 G403 S404 G405 H406 S407 N408 T436 M457 R486 M573 H574 F595 R597 F599 R600 R607 M619 S632 K645 K648 S651	K56 V57 V80 S81 G82 S84 K87 C88 F89 F90 L93 T103 Q105 I106 N109 K138 E139 A140 Q248 E251 Q252 V255 E256 K361 T362 R363 T390 G391 S392 G393 H394 S395 N396 T424 M445 R474 M561 H562 F583 R585 F587 R588 R595 M607 S620 K633 K636 S639
BS02	ZN	A	C554 C557 C610 C613	C542 C545 C598 C601
BS03	ADP	A	E2 H4 Q7 G27 G29 K30 T31 R32 E67 D444 R471	E2 H4 Q7 G27 G29 K30 T31 R32 E67 D432 R459
BS04	ALF	A	T26 K30 E132 G442 R469 R471	T26 K30 E132 G430 R457 R459

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0045087 innate immune response

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5jbg, PDBe:5jbg, PDBj:5jbg
• PDBsum: 5jbg
• PubMed: 27203181
• UniProt: G0YYQ5