Structure of PDB 5jax Chain A

Receptor sequence
>5jaxA (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
IKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGD
TFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVI
AAEAVTCLVIDRDSFKHLIGGLDDVSNKAY
3D structure
PDB5jax Structural Basis of Analog Specificity in PKG I and II.
ChainA
Resolution1.486 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6J7 A V283 L296 R297 L299 F305 G306 E307 K308 A309 R316 T317 Y351 V62 L75 R76 L78 F84 G85 E86 K87 A88 R95 T96 Y130
BS02 CA A G342 D344 G121 D123
BS03 CA A R269 D271 D314 R48 D50 D93
Gene Ontology
Molecular Function
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5jax, PDBe:5jax, PDBj:5jax
PDBsum5jax
PubMed28793191
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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