Structure of PDB 5j9l Chain A

Receptor sequence
>5j9lA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
SLHMIDYKEIEVEEVVGRGGVVCKAWRADVAIKQIESESERKAFIVELRQ
LSRVNHPNIVKLYCLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS
WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGSAAWM
APEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG
TRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADE
PLQYPCQHSLPPGEDGRVEPYVDFAEFYRLWSVDHG
3D structure
PDB5j9l Structure-guided development of covalent TAK1 inhibitors.
ChainA
Resolution2.7515 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 K158 P160 N161 I173 D175
Catalytic site (residue number reindexed from 1) D124 K126 P128 N129 I141 D143
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6HF A V42 V50 A61 M104 Y106 A107 G110 S111 P160 L163 F176 V16 V22 A31 M72 Y74 A75 G78 S79 P128 L131 F144 PDBbind-CN: -logKd/Ki=7.47,IC50=34nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5j9l, PDBe:5j9l, PDBj:5j9l
PDBsum5j9l
PubMed28011204
UniProtO43318|M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (Gene Name=MAP3K7);
Q15750|TAB1_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Gene Name=TAB1)

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