Structure of PDB 5j94 Chain A

Receptor sequence
>5j94A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
YIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSSWAFSSVGALEGQLKKKT
GKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQ
EESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSF
QFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKG
YILMARNKNNACGIANLASFPKM
3D structure
PDB5j94 A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods.
ChainA
Resolution2.22002 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 S25 H162 N182
Catalytic site (residue number reindexed from 1) Q27 S33 H170 N190
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1XF A G-1 K119 K122 R123 K176 N199 G7 K127 K130 R131 K184 N207 BindingDB: IC50=80000nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5j94, PDBe:5j94, PDBj:5j94
PDBsum5j94
PubMed24518821
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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