Structure of PDB 5j8d Chain A

Receptor sequence
>5j8dA (length=216) Species: 550 (Enterobacter cloacae) [Search protein sequence]
DIISVALKRHSTKAFDASKKLTAEEAEKIKTLLQYSPSSTNSQPWHFIVA
STEEGKARVAKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQ
EEADGRFNTPEAKAANHKGRTYFADMHRVDLKDDDQWMAKQVYLNVGNFL
LGVGAMGLDAVPIEGFDAAILDEEFGLKEKGFTSLVVVPVGHHSVEDFNA
TLPKSRLPLSTIVTEC
3D structure
PDB5j8d Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K14 K74 E165
Catalytic site (residue number reindexed from 1) K13 K73 E164
Enzyme Commision number 1.-.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A R10 H11 S12 K14 N71 P163 I164 E165 G166 K205 R207 R9 H10 S11 K13 N70 P162 I163 E164 G165 K204 R206
BS02 DND A K14 N71 K74 G166 F199 L203 K13 N70 K73 G165 F198 L202
BS03 DND A S40 T41 R107 F108 F124 S39 T40 R106 F107 F123
BS04 FMN A P38 S39 S40 N42 P37 S38 S39 N41
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0046256 2,4,6-trinitrotoluene catabolic process
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:5j8d, PDBe:5j8d, PDBj:5j8d
PDBsum5j8d
PubMed28578873
UniProtQ01234|NFSB_ENTCL Oxygen-insensitive NAD(P)H nitroreductase (Gene Name=nfsB)

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