Structure of PDB 5j7s Chain A

Receptor sequence
>5j7sA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
SLHMIDYKEIEVEEVVGRGGVVCKAKWRAKDVAIKKAFIVELRQLSRVNH
PNIVKLYLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ
GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGSAAWMAPEVFEG
SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIK
NLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQ
HSLPPGEDGRVEPYVDFAEFYRLWSVDHG
3D structure
PDB5j7s Structure-guided development of covalent TAK1 inhibitors.
ChainA
Resolution2.368 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 K158 P160 N161 I173 D175
Catalytic site (residue number reindexed from 1) D117 K119 P121 N122 I134 D136
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6H3 A V42 V50 M104 Y106 A107 L163 C174 F176 V16 V22 M65 Y67 A68 L124 C135 F137 PDBbind-CN: -logKd/Ki=7.30,IC50=50nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5j7s, PDBe:5j7s, PDBj:5j7s
PDBsum5j7s
PubMed28011204
UniProtO43318|M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (Gene Name=MAP3K7);
Q15750|TAB1_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Gene Name=TAB1)

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