Structure of PDB 5j7g Chain A

Receptor sequence
>5j7gA (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
MQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRL
YDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB5j7g 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6GG A L54 L57 G58 I61 Y67 F86 V93 H96 I99 Y100 L38 L41 G42 I45 Y51 F70 V77 H80 I83 Y84 PDBbind-CN: -logKd/Ki=7.24,IC50=0.058uM
BindingDB: Ki=58nM
BS02 6GG A Y67 Q72 Y51 Q56 PDBbind-CN: -logKd/Ki=7.24,IC50=0.058uM
BindingDB: Ki=58nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5j7g, PDBe:5j7g, PDBj:5j7g
PDBsum5j7g
PubMed28482147
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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