Structure of PDB 5j7b Chain A

Receptor sequence
>5j7bA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLLLDSE
RKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHR
KTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFH
VKIADFGLGTIIYMPPENYESRASIKHDIYSYAVITWEVLSRKQPFEDVT
NPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSF
LKCLIELEPVLRTFEEITFLEAVIQLK
3D structure
PDB5j7b The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
ChainA
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 K148 Q150 N151 D164 T189
Catalytic site (residue number reindexed from 1) D137 K139 Q141 N142 D155 T160
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6GD A L24 S25 A45 K47 L79 I93 T95 M98 G101 E105 L153 D164 L20 S21 A41 K43 L70 I84 T86 M89 G92 E96 L144 D155 PDBbind-CN: -logKd/Ki=8.30,IC50=5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5j7b, PDBe:5j7b, PDBj:5j7b
PDBsum5j7b
PubMed27109867
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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