Structure of PDB 5j74 Chain A

Receptor sequence

>5j74A (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]

VQLVESEAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGT
IPIFGTADYAQEFQGRVTITTDESTSTAYMELSGLRSEDTAVYYCVLLGT
TMVTGHYFDYWGQGTLVTVNFMLTQPPSASGTPGQSVTISCSGSGSNIGN
NKVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQS
EDEADYYCAAWDDGLSGYVFGTGTKLTVLAA

3D structure

PDB

5j74 Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair.

Chain

Resolution

2.7 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	6GN	A	S35 W47 L99 Y108 K175 Y179 W234 Y241	S34 W46 L98 Y107 K152 Y156 W211 Y218	PDBbind-CN: -logKd/Ki=8.72,Kd=1.9nM

External links

PDB	RCSB:5j74, PDBe:5j74, PDBj:5j74
PDBsum	5j74
PubMed	26442911

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