Structure of PDB 5j5t Chain A

Receptor sequence
>5j5tA (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQE
IIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSEL
QIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQI
TATIAAFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPM
FDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTA
EKLLQHPFVTQHLTRSLAIELLDKVNNPSTYHDFDDDDPEPLVAVPHR
3D structure
PDB5j5t Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D136 K138 A140 N141 D154 A163 T174
Catalytic site (residue number reindexed from 1) D125 K127 A129 N130 D143 A152 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6G2 A I22 V30 A43 M90 F92 C93 G96 L143 D154 I11 V19 A32 M79 F81 C82 G85 L132 D143 PDBbind-CN: -logKd/Ki=6.96,IC50=110nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5j5t, PDBe:5j5t, PDBj:5j5t
PDBsum5j5t
PubMed27727493
UniProtQ8IVH8|M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3 (Gene Name=MAP4K3)

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