Structure of PDB 5j4v Chain A

Receptor sequence
>5j4vA (length=358) Species: 10632 (JC polyomavirus) [Search protein sequence]
TKQVSWKLVTQYALDTKCEDVFLLMGMYLNFQEAPAACAACAAADQPNHF
NHHEKHYYNAQIFADSKNQKSICQQAVDTVAAKQRVDSLHMTREEMLVER
FNFLLDKMDLIFGAHGNAVLEQYMAGVAWIHCLLPQMDTVIYEFLKCIVL
NIPKKRYWLFKGPIDSGKTTLAAALLDLCGGKSLNVNMPLERLNFELGVG
IDQFMVVFEDVKGTGAESRDLPSGHGISNLDCLRDYLDGSVKVNLERRTQ
VFPPGIVTMNEYSVPRTLQARFVRQIDFRPKAYLRKSLSCSEYLLEKRIL
QSGMTLLLLLIWFRPVADFAAAIHERIVQWKERLDLEISMYTFSTMKANV
GMGAPILD
3D structure
PDB5j4v Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors.
ChainA
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C303 C306 H314 H318 C38 C41 H49 H53
BS02 6JH A W394 L398 D430 S431 G432 P550 K551 L554 R555 L558 L565 W129 L133 D165 S166 G167 P280 K281 L284 R285 L288 L295 PDBbind-CN: -logKd/Ki=5.85,IC50=1.4uM
BindingDB: IC50=1400nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5j4v, PDBe:5j4v, PDBj:5j4v
PDBsum5j4v
PubMed27385654
UniProtP03072|LT_POVJC Large T antigen

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