Structure of PDB 5j4n Chain A

Receptor sequence
>5j4nA (length=437) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]
ADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGAL
GLSMVYAKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAM
VVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVA
TVLALIPIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSF
IGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVLSTTAIMGMIPNAA
LRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAA
ADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVS
SVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVG
SGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAP
3D structure
PDB5j4n Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC.
ChainA
Resolution2.594 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AG2 A I23 A96 C97 G100 N101 M104 W293 I19 A92 C93 G96 N97 M100 W289 PDBbind-CN: -logKd/Ki=4.25,Ki=56uM
Gene Ontology
Molecular Function
GO:0015297 antiporter activity
GO:0022857 transmembrane transporter activity
GO:0043862 arginine:agmatine antiporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006865 amino acid transport
GO:0015695 organic cation transport
GO:0055085 transmembrane transport
GO:1905039 carboxylic acid transmembrane transport
GO:1990451 cellular stress response to acidic pH
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5j4n, PDBe:5j4n, PDBj:5j4n
PDBsum5j4n
PubMed27582465
UniProtP60061|ADIC_ECOLI Arginine/agmatine antiporter (Gene Name=adiC)

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