Structure of PDB 5j3s Chain A

Receptor sequence
>5j3sA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
HMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYL
KKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCV
HVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAVIFAGDTNLR
DREVTRSGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFD
RIFFRIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLD
3D structure
PDB5j3s Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6FQ A R231 R266 I307 C311 R120 R150 I191 C195 PDBbind-CN: -logKd/Ki=7.72,IC50=19nM
BindingDB: IC50=590nM,EC50=40nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5j3s, PDBe:5j3s, PDBj:5j3s
PDBsum5j3s
PubMed27099339
UniProtO95551|TYDP2_HUMAN Tyrosyl-DNA phosphodiesterase 2 (Gene Name=TDP2)

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