Structure of PDB 5j20 Chain A

Receptor sequence
>5j20A (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
AVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLT
DPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGT
KAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESS
AGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIG
YPITLFVE
3D structure
PDB5j20 Protein conformational flexibility modulates kinetics and thermodynamics of drug binding.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6FJ A N51 A55 D93 I96 G97 M98 L103 L107 F138 V150 W162 V186 N36 A40 D78 I81 G82 M83 L88 L92 F123 V135 W147 V171 MOAD: Kd=0.000000064M
PDBbind-CN: -logKd/Ki=9.14,Kd=0.72nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:5j20, PDBe:5j20, PDBj:5j20
PDBsum5j20
PubMed29273709
UniProtP07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (Gene Name=HSP90AA1)

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