Structure of PDB 5j18 Chain A

Receptor sequence
>5j18A (length=82) Species: 9606 (Homo sapiens) [Search protein sequence]
SPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRI
QDGEKKPIGWDTDISWLTGEELHVEVLENVPL
3D structure
PDB5j18 A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6FS A K154 I156 R166 T167 V168 M187 K4 I6 R16 T17 V18 M37 PDBbind-CN: -logKd/Ki=9.15,Kd=0.71nM
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:5j18, PDBe:5j18, PDBj:5j18
PDBsum5j18
PubMed27104980
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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