Structure of PDB 5j0d Chain A

Receptor sequence
>5j0dA (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]
RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVK
NPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSK
LAEVFEQEIDPVMQSLG
3D structure
PDB5j0d Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors.
ChainA
Resolution1.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6F9 A L1109 P1110 F1111 V1115 N1168 R1173 V1174 F1177 L29 P30 F31 V35 N88 R93 V94 F97 MOAD: Kd=134nM
PDBbind-CN: -logKd/Ki=6.87,Kd=134nM
BindingDB: Kd=134nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5j0d, PDBe:5j0d, PDBj:5j0d
PDBsum5j0d
PubMed27673482
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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