Structure of PDB 5iz9 Chain A

Receptor sequence
>5iz9A (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
MLHLLEQIRAYCETCWEWQEAHEPGNPMPAPVEHQICPAVCVLMKLSFDE
EHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTF
GDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSK
KTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVD
GALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN
CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNL
IHSKHKMIAMGSAAALRNLMANRPAKYK
3D structure
PDB5iz9 Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
ChainA
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T506 N507 F510 G511 K516 R549 N550 W553 S590 W593 N594 T96 N97 F100 G101 K106 R139 N140 W143 S180 W183 N184
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iz9, PDBe:5iz9, PDBj:5iz9
PDBsum5iz9
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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