Structure of PDB 5iz6 Chain A

Receptor sequence
>5iz6A (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHMLHLLEQIRAYCETCWEWQEAHNPMPAPVEHQICPAVCVLMKLSFDE
EHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTF
GDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSK
KTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVD
GALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN
CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNL
IHSKHKMIAMGSAAALRNLMANRPAKYKDAN
3D structure
PDB5iz6 Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R463 M503 T506 N507 F510 G511 K516 Q542 V543 R549 N550 W553 W593 N594 A597 N641 R53 M93 T96 N97 F100 G101 K106 Q132 V133 R139 N140 W143 W183 N184 A187 N231
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iz6, PDBe:5iz6, PDBj:5iz6
PDBsum5iz6
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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