Structure of PDB 5ixi Chain A

Receptor sequence
>5ixiA (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
VEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENT
KLWYAPNRTITVMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPTPLLDAS
SLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMM
KKMSYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVS
THDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSVLYYEVMV
TGNLGIQWRHKPEEWNNFSFFPEITHIVIKESVVSINKQDNKKMELKLSS
HEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEY
AINKLRQEYVLRWSCTDFDNILMTNFQIEVQKGRYSLHGSDRSFPSLGDL
MSHLKKQILRTDNISFMLKRCCQPKPREISNLLVAT
3D structure
PDB5ixi The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
ChainA
Resolution2.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q180 H183 E186 N187 E188 L190 G191 L195 R232 N233 L235 T236 R239 I240 D246 F247 F251 S259 V261 K269 Q127 H130 E133 N134 E135 L137 G138 L142 R170 N171 L173 T174 R177 I178 D184 F185 F189 S197 V199 K207
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ixi, PDBe:5ixi, PDBj:5ixi
PDBsum5ixi
PubMed27133025
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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