Structure of PDB 5ixd Chain A

Receptor sequence
>5ixdA (length=420) Species: 9606 (Homo sapiens) [Search protein sequence]
VEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENT
KLWYAPNRTITVMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPTPLLDAS
SLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMM
KKMQLPELPISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKT
ICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSL
YYEVMVTGNLGIQWRHKPNEEWNNFSFFPEITHIVIKESVVSINKQDNKK
MELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCH
GPICTEYAINKLRQEYVLRWSCTDFDNILIEVQKRYSLHGSDRSFPSLGD
LMSHLCQPKPREISNLLVAT
3D structure
PDB5ixd The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q180 H183 D184 E186 N187 E188 G191 V194 L195 N233 L235 R239 I240 F247 E250 F251 V261 K269 Q127 H130 D131 E133 N134 E135 G138 V141 L142 N178 L180 R184 I185 F192 E195 F196 V206 K214
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ixd, PDBe:5ixd, PDBj:5ixd
PDBsum5ixd
PubMed27133025
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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