Structure of PDB 5ix1 Chain A

Receptor sequence

>5ix1A (length=414) Species: 10090 (Mus musculus) [Search protein sequence]

GIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVI
SDHICLTFTDNGNGMTADKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSG
SMRLGKDAMVFTKNGETMSVGFLSQTYLEVIKAEHVVVPIVTFNKHRQMI
NLTESKASLAAILEHSLFSTEQKLLAELNAIMGKKGTRIIIWNLRSYKNA
TEFDFEKDKYDIRIPEDYKKQEIAPESDYSLRAYCSILYLKPRMQIIIRG
QKVKTQLVSKSLAYIERDVYRPKFLTRTVRITFGFNCRNKDHYGIMMYHK
NRLIKAYEKVGCQNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTILAL
GEKLNDYWNEMKKRPDQTWVQCDACLKWRKLPDGIDQLPEKWYCSNNPDP
QFRNCEVPEEPEDE

3D structure

PDB

5ix1 Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Y217 G270 R405 P406 D407 Q408 T409 W410 V411 Q412 W419 D424 E431 D454	Y210 G250 R364 P365 D366 Q367 T368 W369 V370 Q371 W378 D383 E390 D413
BS02	ZN	A	C413 C435 C446	C372 C394 C405
BS03	ANP	A	N39 V45 M72 M80 S86 K88 G98 L99 Y100 G101 N102 G103 F104 K358	N32 V38 M65 M73 S79 K81 G91 L92 Y93 G94 N95 G96 F97 K334

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding
GO:0016887	ATP hydrolysis activity

View graph for
Molecular Function

External links

PDB	RCSB:5ix1, PDBe:5ix1, PDBj:5ix1
PDBsum	5ix1
PubMed	27528681
UniProt	F7BJB9\|MORC3_MOUSE MORC family CW-type zinc finger protein 3 (Gene Name=Morc3)

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