Structure of PDB 5iwg Chain A

Receptor sequence
>5iwgA (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
GKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRP
HKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGL
FEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDI
VLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFP
GTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSA
VVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIR
NVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTP
EYMEKIKQRLFENLRMLP
3D structure
PDB5iwg Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
ChainA
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D181 H183 D269 D170 H172 D258
BS02 CA A D179 D181 H183 S202 F203 D168 D170 H172 S191 F192
BS03 IWX A M35 R39 F114 L144 H145 H146 G154 F155 C156 D181 H183 L276 G305 G306 Y308 M24 R28 F103 L133 H134 H135 G143 F144 C145 D170 H172 L265 G294 G295 Y297 MOAD: Ki=0.346uM
PDBbind-CN: -logKd/Ki=6.46,Ki=0.346uM
BindingDB: IC50=62nM
BS04 CA A F192 T195 V198 Y227 F181 T184 V187 Y216
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:5iwg, PDBe:5iwg, PDBj:5iwg
PDBsum5iwg
PubMed27377864
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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