Structure of PDB 5ivv Chain A

Receptor sequence
>5ivvA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
EFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPF
ACEVKSFRFTPRVQRLNELEAMAFGFEQAVREYTLQSFGEMADNFKSDYF
NMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGR
RKILPEEEEYALSGWNLNNMPVLEQSVLKVPWLYVGMCFSSFCWHIEDHW
SYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVT
IMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCT
3D structure
PDB5ivv Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
ChainA
Resolution1.848 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y184 H195 E197 H283 A295
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6EN A R73 Y409 A411 D412 Y472 F480 H483 K501 W503 H571 R62 Y131 A133 D134 Y184 F192 H195 K213 W215 H283 MOAD: Kd=0.45uM
PDBbind-CN: -logKd/Ki=6.35,Kd=0.45uM
BindingDB: IC50=<100nM
BS02 MN A H483 E485 H571 H195 E197 H283
External links
PDB RCSB:5ivv, PDBe:5ivv, PDBj:5ivv
PDBsum5ivv
PubMed27427228
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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