Structure of PDB 5ivj Chain A

Receptor sequence
>5ivjA (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
EFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPF
ACEVKSFRFTPRVQRLNELEAMGFEQAVREYTLQSFGEMADNFKSDYFNM
PVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRK
ILPEEEEYALSGWNLNNMPVLEQSKVPWLYVGMCFSSFCWHIEDHWSYSI
NYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNP
NVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCT
3D structure
PDB5ivj Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
ChainA
Resolution1.569 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y180 H191 E193 H279 A291
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6ED A R73 Y409 A411 D412 Y472 F480 H483 K501 W503 H571 R62 Y129 A131 D132 Y180 F188 H191 K209 W211 H279 MOAD: Kd=0.046uM
PDBbind-CN: -logKd/Ki=7.34,Kd=0.046uM
BindingDB: IC50=<100nM
BS02 MN A H483 E485 H571 H191 E193 H279
External links
PDB RCSB:5ivj, PDBe:5ivj, PDBj:5ivj
PDBsum5ivj
PubMed27427228
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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